HIV-Envelope–Dependent Cell-Cell Fusion: Quantitative Studies
نویسندگان
چکیده
منابع مشابه
HIV-Envelope–Dependent Cell-Cell Fusion: Quantitative Studies
Interaction in vitro between cells infected with human immunodeficiency virus (HIV) and surrounding, uninfected, target cells often leads to cell fusion and the formation of multinucleated cells, called syncytia. The presence in HIV-infected individuals of virus strains able to induce syncytia in cultures of T cells is associated with disease progression and AIDS. Even in the asymptomatic stage...
متن کاملStudies on chemically induced cell fusion.
Hen erythrocytes that were fixed after treatment with lysolecithin in aqueous solution for 30 s at 37 °C showed evidence of bridge formation between adjacent lysed cells. Generally, the homokaryons that were produced using lysolecithin in this way contained large numbers of nuclei. These giant syncytia had damaged nuclear membranes and unstable plasma membranes; complete disintegration of the s...
متن کاملOptimizing Dendritic Cell Preparation for Fusion with Melanoma Cells
Background: Fusion of dendritic cells (DCs) with melanoma cells could reinforce the antigenicity of tumors as a strategy for the treatment of malignant melanoma. However, the insufficient quantity of DCs and the low fusion efficiency limits the development of such approach. Objective: To define the dosage of the stimulating factors as well as the induction condition for the optimal DCs prepara...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2009
ISSN: 1537-744X
DOI: 10.1100/tsw.2009.90